ABSTRACT
This study conducted at the Research Institute for Tropical Medicine from April 1990 to December 1992, identified the etiology of acute lower respiratory tract infection (ALRI) in 119 (36.9%) of 317 hospitalized children < 5 years of age. A higher proportion of respiratory viruses (27.2%) than bacterial agents (10.7%) were identified. Viral agents (adenovirus, RSV, parainfluenza 3, influenza A and influenza B) and bacterial agents (mainly Haemophilus influenzae and Streptococcus pneumoniae) are the pathogenic agents involved in ALRI among Filipino children less than 5 years old.
Subject(s)
Bacteremia/diagnosis , Child, Preschool , Cross-Sectional Studies , Developing Countries , Female , Humans , Incidence , Infant , Male , Philippines/epidemiology , Pneumonia, Bacterial/diagnosis , Pneumonia, Viral/diagnosis , Respiratory Tract Infections/diagnosisABSTRACT
In an open clinical trial, thirty patients 14 to 44 years old and with acute uncomplicated falciparum malaria were given halofantrine hydrochloride 500 mg (2 tablets) 6-hourly for 3 doses, a total dose of 1500 mg. All 30 patients were cured, with a mean asexual parasite clearance time of 47.6 hours and mean fever clearance time of 36.6 hours. Post-dosing side-effects occurred in 6 patients consisting of mild to moderate headache, dizziness and abdominal muscle spasm. Drug-induced hemolysis did not occur in two G6PD deficient patients. Twenty-three out of 28 isolates tested (82%) were resistant to amodiaquine, 3 (11%) were resistant to the sulfadoxine-pyrimethamine combination, and all were sensitive to chloroquine, quinine and mefloquine by in vitro microtests. The study confirms the efficacy of halofantrine hydrochloride as a blood schizonticide in falciparum malaria.
Subject(s)
Acute Disease , Administration, Oral , Adolescent , Adult , Blood Cell Count , Blood Chemical Analysis , Drug Resistance , Hematocrit , Hemoglobins/analysis , Humans , Malaria, Falciparum/blood , Parasite Egg Count , Phenanthrenes/administration & dosageABSTRACT
The usefulness of a single Widal test was evaluated in an endemic area. This test was done on 62 bacteriologically proven enteric fever cases, 69 non-enteric fever cases and healthy individuals. Using an 0 antibody cut-off of greater than or equal to 1:20, the Widal tube agglutination test yielded a sensitivity of 61% and a specificity of 88%. At a pre-test probability of around 50%, the positive predictive value was 83% and the negative predictive value was 72%. A 4% prevalence of 0 antibodies was noted in the healthy population.
Subject(s)
Adolescent , Adult , Agglutination Tests/standards , Evaluation Studies as Topic , Female , Humans , Male , Philippines/epidemiology , Prevalence , Sensitivity and Specificity , Typhoid Fever/bloodABSTRACT
Clinical trials on oral clindamycin as an antimalarial in hospitalized patients and residents of endemic communities were conducted in the Philippines between May 1984 and December 1985. Seven and 9 qualified subjects in hospital were treated with 300 mg (regimen A) and 600 mg (regimen B) respectively, twice daily for 5 days. Eighteen patients seen at a rural health unit were given the lower dosage. On the basis of the 28-day extended in vivo test of WHO, P. falciparum in all but one patient showed susceptibility to the drug as a blood schizontocide hence, the clinical cure of malaria. Side effects were few and self-limiting. Ten other patients on regimen A were cured within the 7- and/or 28-day extended test period. Clindamycin per se is currently one of the few alternatives in the treatment of clinically moderate drug-resistant malaria.
Subject(s)
Acute Disease , Administration, Oral , Adolescent , Adult , Animals , Child , Clindamycin/therapeutic use , Female , Humans , Malaria/diagnosis , Male , Middle Aged , Parasite Egg Count , Plasmodium falciparum , Prospective StudiesABSTRACT
A total of 40 rotavirus specimens obtained from infants with acute gastroenteritis in Metro Manila, Philippines, were analyzed for their subgroup and serotype specificities and RNA electropherotype. A half (50%) of the specimens contained subgroup I human rotaviruses (HRVs), while 45% of them contained subgroup II HRVs. All subgroup II HRVs were determined to be serotype 1, except one specimen belonging to serotype 3, by an enzyme-linked immunosorbent assay with serotype specific monoclonal antibodies. However, serotype specificity of all subgroup I specimens failed to be determined. In polyacrylamide gel electrophoresis, RNAs extracted from HRVs of either subgroup showed long electropherotype. At least two electropherotypes were distinguished in subgroup I viruses, while five different patterns of viral RNA were found in subgroup II viruses.
Subject(s)
Child, Preschool , Electrophoresis, Gel, Two-Dimensional , Enzyme-Linked Immunosorbent Assay , Female , Gastroenteritis/epidemiology , Humans , Infant , Infant, Newborn , Male , Philippines/epidemiology , RNA/analysis , Rotavirus/classification , Rotavirus Infections/epidemiology , Seroepidemiologic Studies , SerotypingABSTRACT
From 1982 to 1988, Shigella was detected in 4% of stool specimens cultured at The Research Institute for Tropical Medicine (RITM), Manila. S. flexneri was the most prevalent serogroup with 2a, 1b and 1a as the predominant serotypes. Isolation was most frequent during the July to December period. Drug resistance was most often observed in S. flexneri with serotype 2a exhibiting resistance to the combination of ampicillin, chloramphenicol, tetracycline and streptomycin. More multiple-drug than single-drug resistant strains were observed for the last four years. Ampicillin is still the most frequently used drug for most forms of shigellosis in the Philippines. However, the demonstration of increasing resistance among the isolates studied in RITM underscores the need to monitor antibiotic susceptibility studies and document the emergence of resistant strains in the entire country.